Scientist II

About the job
Client is a leading company in Global Healthcare that discovers, develops, produces, and markets innovative therapies to help protect health and enhance people s lives. We are seeking a highly motivated in-vivo pharmacologist to join the Type 2 Immunology Cluster within the Immunology and Inflammation Therapeutic Area located in Cambridge, MA. The ideal candidate will possess a strong background in in-vivo pharmacology, contributing technical skills and functional knowledge. The candidate will also be involved in the design, overall conduct, and the reporting of in-vivo pharmacology study results to project teams. The position is a hands-on, laboratory-based role that requires strong communication skills, attention to detail, a results-driven way of working, and ability to work both individually and in a team environment, and to work across functions. A successful candidate is expected to analyze, record and report data, be able to develop and learn new techniques, and be able to multi-task between multiple projects.

Main Responsibilities:
Responsible for designing and performing in-vivo pharmacology experiments in support of project team goals. This includes study design, data collection and recording, communication of results, and report writing.
Summarize and present study data to project teams within established timelines.
Generate specific pharmacology reports based on studies performed to support IND submission.
Capacity to use established procedures and methodologies with the ability to transform Client approaches into routine practice.
Use detailed knowledge of state-of-the-art tools and approaches to enhance in vivo evaluation of Client therapeutics mechanism of action and/or identify new targets.
Identify and develop ex vivo analytical tools that can be used to maximize the read-outs from in vivo studies
Must be a technical contributor.
Ability to troubleshoot experiments.
Support the development of disease relevant in-vivo models.
Must be well organized and detail oriented.
Must have meticulous record keeping skills according to Client quality guidelines. Maintain a thorough and compliant laboratory notebook.
Must adhere to all federal, local, and Client animal welfare guidelines.
Must be capable of working alone and in a team environment.
Qualifications:
Deep knowledge of immunology, mechanistic understanding of autoimmune or inflammatory pathologies. Proficiency in establishing in vivo PK/PD and efficacy models of immunology/autoimmune diseases (e.g. DTH, DSS, T cell transfer model, ovalbumin induced asthma...).
Extensive in vivo pharmacology expertise in working with rodent inflammatory models and in molecular, cellular biology and immunological assays (e.g. Flow cytometry, cytokine measurement) required. Well-established hands-on experience with in vivo dosing, bleeding, and handling techniques and proficiency in basic surgical techniques.
Experience with compound or reagent preparation.
Ability to work under moderate supervision with regular review of results and methods utilized.
Ability to present study related results to project teams.
Proven ability to work in a dynamic, customer-focused and results-oriented environment.
Education and Experience:
Master s Degree plus a minimum of 3 years of relevant research experience in a biopharmaceutical setting OR a Ph.D. in Immunology, Pharmacology with relevant research experience in academic facility or biopharmaceutical setting.