Bench Scientist

Pay- $42.4/hr on W2

Job Description (Required):
We are looking for an energetic and experienced mass spectrometry scientist to join our Research Client Characterization team in the Protein Solutions and Bioanalytical department. This individual will help us grow our mass spectrometry capabilities, lead the development of new or improved techniques for the characterization of proteins and antibody drug conjugates in various matrices, as well as maintain our shared mass spectrometers. They will also participate in collaborative, cross-functional teams to enable cancer therapeutic development and aid in exploring scientific questions surrounding antibody-based therapeutic activity and behavior.

POSITION RESPONSIBILITIES:
Determine and develop Client and appropriate LC-MS methods for the characterization of intact ADCs, antibodies, and other proteins
Develop and optimize both broadly applicable and fit-for-purpose methodologies for the capture, characterization, and quantification of proteins and conjugates from biological samples
Perform pepProduct mapping to deeply characterize proteins and bioconjugates
Provide care, maintenance, and troubleshooting of shared LC-MS instrumentation, including training new users and developing and maintaining best practices
Provide technical and scientific advice and support to scientists of all levels, advise on LC and mass spectrometry related questions, and provide sample processing and data analysis for non-MS users
Practice continuous improvement to refine methods and optimize processes, staying in touch with relevant literature and state of the art technologies
Maintain strong communication and collaborative relationships with mass spectrometry groups outside of Research
Create and organize technical information to deliver effective presentations in multiple forums

ORGANIZATIONAL RELATIONSHIPS:
Working primarily with Protein BioAnlaytical Solutions (PBS) Conjugation group and Antibody Design and Engineering (AD&E) groups with some interactions with the Chemistry group.

EDUCATION AND EXPERIENCE:
A Ph.D. or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry
4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas
Demonstrated experience in the operation and maintenance of mass spectrometers, their software, and applicable data analysis software
Established capability in biological characterization and data analysis, specifically utilizing mass spectrometry techniques
Attention to detail and a strong analytical mindset capable of proposing sound experimental strategies and developing new LC-MS protocols
Uses critical thinking to solve complex problems, address challenges, overcome obstacles, and anticipate areas for growth
Established safe laboratory skills and accurate record keeping
Ability to work independently on routine experiments

TECHNICAL SKILLS REQUIREMENTS:
Preferred qualifications include:
Hands-on experience working with a Waters Xevo G2S QTof, Thermofisher Q Exactive, and/or SCIEX X500B QTOF
Familiarity with affinity purification of proteins, pepProducts and/or metabolites.
Experience analyzing all types of recombinant proteins
Experience identifying and characterizing post-translational modifications or enzymatic modifications of proteins
Experience with protein conformational analysis, such as Hydrogen deuterium exchange mass spectrometry
Familiarity with Protein Metrics software and reporting, including high throughput data processing
Experience or familiarity with mass spectrometry automation
Knowledge of SEC-MALS biological analysis methods

PHYSICAL POSITION REQUIREMENTS:
Cytotoxic small molecules that are alone or attached to antibodies
Organic solvents
Rodent plasma


Hard Skills:
1. LCMS
2. Large molecule
3. Anitbody exp.

Nice to Have
1. ABC's
2. Zenotof 7600
3. Organized/Detailed Oriented/Team Player/Flexible

Interview Process:
1st 15-20min call
2nd Onsite
Position Comments visible to Supplier:
Will overtime be needed?: Yes If Yes, how many hours of overtime (on average) per week?: As business requires with manager pre-approval Work Environment: Onsite What will the resource be working with, or, have exposure to?:

N/A

What is the minimum education experience required?: A Ph.D. or equivalent experience in bioanalytical chemistry, analytical chemistry, pharmaceutical sciences, or a related discipline with recognized and established expertise in mass spectrometry
4+ years of research experience in the biotech/pharmaceutical industry or closely related academic areas