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Job Requirements of Oligonucleotide Analytics - Scientist:
-
Employment Type:
Contractor
-
Location:
San Diego, CA (Onsite)
Do you meet the requirements for this job?
Oligonucleotide Analytics - Scientist
Careers Integrated Resources Inc
San Diego, CA (Onsite)
Contractor
Job Title: Oligonucleotide Analytics - Scientist
Location: La Jolla, CA
Duration 12 Months+
Pay Rate:$52/hr on w2
Notes:
Description:
Key Responsibilities:
Qualifications
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
#sczr2
Location: La Jolla, CA
Duration 12 Months+
Pay Rate:$52/hr on w2
Notes:
- Must be able to commute to work every day
- PhD is required
- Must have experience with Analytical Chemistry
- Must have experience with Oligonucleotides
- Must have siRNA experience
- Previous gene therapy experience
- Must have 1-3 years of experience
- Experience with Chromatography (LC-MS)
- Experience with these instruments: Thermo LTQ, LC/MS or Thermo Orbitrap LC/MS
Description:
Key Responsibilities:
- 30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
- 20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
- 10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
- 20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
- 5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
- Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
- Support integrity confirmation requests (such as concentration) by assay development and biology teams
- 3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
- 5% Ensure the supply of laboratory consumables and reagents are in stock as needed
- Maintain a high level of productivity in the laboratory setting.
- 2% Present data and reports on project status at individual, group, and departmental meetings.
Qualifications
- Ph.D.. with 1-3 years of experience, performing progressively advanced duties at the Scientist level, or the equivalent training/experience is required.
- Prior experience in the characterization of oligonucleotides and/or nucleoside/nucleotide analytes is required.
Top Three Skills: Operate LC-MS systems - Analyze and optimize methods - establish and automate high throughout analytical capabilities
#sczr2
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