US
0 suggestions are available, use up and down arrow to navigate them
PROCESSING APPLICATION
Hold tight! We’re comparing your resume to the job requirements…
ARE YOU SURE YOU WANT TO APPLY TO THIS JOB?
Based on your Resume, it doesn't look like you meet the requirements from the employer. You can still apply if you think you’re a fit.
Job Requirements of Scientist I:
-
Employment Type:
Contractor
-
Location:
Waltham, MA (Onsite)
Do you meet the requirements for this job?
Scientist I
Careers Integrated Resources Inc
Waltham, MA (Onsite)
Contractor
Title: Scientist I
Location: Waltham, MA
Duration: 12 Months+ Possible Extension
Pay Range: $50-$53/hr
Manager Notes:
Key Responsibilities
Location: Waltham, MA
Duration: 12 Months+ Possible Extension
Pay Range: $50-$53/hr
Manager Notes:
- The scientist will support protein and LC-MSbased analyses, with a strong focus on mass spectrometry, chromatography, and biological sample preparation.
- Daily work includes end-to-end digest workflow execution, optimization experiments, operating nano-LC and mass spectrometry platforms, monitoring instrument, running impurity and enzyme kinetic assays
- Utilizing a mix of manual and automated liquid handling systems.
- The role also requires data analysis, experiment design based on team feedback, and clear communication of results through summaries and PowerPoint presentations.
- Ideal candidates hold a Masters degree in Analytical Chemistry, Biochemistry, or a related field with 24 years of relevant biotech or pharma experience (or a PhD with 13 years), particularly with LC-MS impurity monitoring or proteomics/HCP profiling, and have experience with software such as Client, Skyline, or similar pepProduct mapping tools.
- Client is seeking a highly motivated Scientist to join theBioAnalytics Characterization group within the Genomic Medicine Unit BioAnalytics.
- The Genomic Medicine Unit at Client is dedicated to the establishment of best-in-class platforms to support development of life-changing advanced gene therapy products, including recombinant AAV vectors and lipid nanoparticles.
- The BioAnalytics Characterization group uses advanced analytical techniques for in-depth structural and functional characterization of gene therapy products in support of drug development, from pre-candidate selection through commercialization.
- This role is predominantly wet-lab involving sample processing and complex instrumentation operation for LC-MS analysis. As Client BioA supports CMC, a successful candidate should have familiarity working within a regulated environment, documenting analyses in ELN and an understanding of drug development life cycle.
Key Responsibilities
- Perform characterization testing of gene therapy samples to determine and quantify host cell proteins using solid-phase enhanced sample preparation and LC-MS analytical techniques commonly used in proteomics (i.e. proteomic profiling using DDA or DIA, targeted quantitation using MRM or PRM).
- Assist in analytical method development and execute method qualification experiments to establish accuracy, precision, linearity and sensitivity of quantitative method.
- Assist in developing automated liquid handler platforms to increase sample throughput.
- Document all method development and testing activities/results accurately in compliance with internal and regulatory standards.
- Masters degree in Analytical Chemistry, Biochemistry, or a related discipline with 2-4 years of relevant biotechnology or pharmaceutical industry experience, preferably performing impurity monitoring using LC-MS or proteome/HCP profiling or Doctorate degree with 1-3 years of relevant experience in proteomics.
- Effective planning, communication and collaboration skills.
- Strong theoretical understanding of macromolecules (e.g., DNA, RNA, proteins) and their chemical properties.
- LC-MS systems: ThermoOrbitrap Exploris/Eclipse/Fusion Lumos/Astral; Sciex LCMS Triple Quad 6500.
- Software: Skyline, Proteome Discoverer, Byos, Spectronaut.
- Practical, hands-on troubleshooting and programming experience with automation equipment, such as Agilent Bravo LT, Hamilton, Andrew+ or KingFisher.
- Gene therapy experience with AAV or LNP is preferred
Get job alerts by email.
Sign up now!
Join Our Talent Network!