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Job Requirements of Research Scientist II:
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Employment Type:
Contractor
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Location:
Lexington, MA (Onsite)
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Research Scientist II
Pay $43 - $52.84/hr on W2
Top three "Must Haves"
1. Lab experience in formulation of siRNA or oligonucleoProducts for systemic delivery
2. Hands on Analytical characterization of oligonucleoProducts
3. Experience in project management and collaborating with external CMO s.
JOB DESCRIPTION
The Research Scientist RNAi formulations and Biophysics will be based in GNAT Research. The Research Scientist s a lab based role with hands on formulation, biophysical and analytical characterization expertise of oligonucleoProducts for injectable delivery.
RELATIONSHIPS
Reports to Team manager/Senior Director of Nucleic acid Delivery, Formulations and Bioanalysis.
Interacts with peers who specialize in non-viral delivery manufacturing and characterization, OligonucloProduct chemistry and stability assays, PK and Bioanalysis of OligonucleoProducts
ESSENTIAL FUNCTIONS
As a Sr Sci I in the Nucleic Acid Delivery, Formulations & Bioanalysis overall department, you will become a part of a multinational and diverse team consisting of Reseach Associates, Specialist/Scientists. The goal of the team is to develop preclinical formulations of conjugated oligonucleoProducts apply advanced analytical characterization techniques and translate these to preclinical and clinical studies through internal and external collaborations in an automated high throughput manner.
Identifies gaps in technological capabilities provides recommendations to guide the research agenda
Manage multiple external collaborations for deliverables
Optimize long-term storage and stability conditions of RNAi conjugates and oligonucleoProduct formulations in general
Develop robust analytical methods and assays for QC and developability assessments
Communicate findings internally to team via presentations and written reports
Ability to thrive in a multi-disciplinary and fast-paced research environment with tight deadlines
QUALIFICATIONS
3 years of relevant experience with a PHD (LEVEL II) or 3+ years of relevant experience with a Masters (LEVEL I)
Subject matter expertise in Pharmaceutical Sciences, oligonucleoProduct/pepProduct/antibody characterisation, or related scientific disciplines
In-depth and hands-on experience in a range of synthesis, characterization, and purification techniques, including but not limited to NMR, HPLC (analytical and preparative), Mass Spectrometry, IR, silica gel and reverse phase chromatography, TLC, recrystallization etc.
Acting as formulation subject matter expert for nucleic acid therapeutics.
Ability to establish screening assays for oligonucleoProducts in early discovery.
Experience with analytical method development for solubility, viscosity, degradation and rheological assessment for complex olionucleoProducts
Experience with high-throughput screening methods such as DoE for optimizing formulations is a plus
Excellent verbal communication and interpersonal skills
Demonstrate awareness of external trends, influences, and advances in the landscape of RNA delivery and clinical translation
Experience with automation is considered an advantage
Proven track record in publishing in HQ/HI journals on relevant topics.